解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Escherichia coli sequence type 131 (ST131), a pandemic clone responsible for the high incidence of extraintestinal pathogenic E. coli (ExPEC) infections, has been known widely for its contribution to the worldwide dissemination of multidrug resistance. Although other ExPEC-associated and extended-spectrum-β-lactamase ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01596-17
更新日期:2017-10-24 00:00:00
abstract::Malaria parasite ookinetes must traverse the vector mosquito midgut epithelium to transform into sporozoite-producing oocysts. The Anopheles innate immune system is a key regulator of this process, thereby determining vector competence and disease transmission. The role of Anopheles innate immunity factors as agonists...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01631-17
更新日期:2017-10-17 00:00:00
abstract::Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a need to expand the chemical ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01474-17
更新日期:2017-10-10 00:00:00
abstract::Transposon insertion sequencing (TIS) is a powerful high-throughput genetic technique that is transforming functional genomics in prokaryotes, because it enables genome-wide mapping of the determinants of fitness. However, current approaches for analyzing TIS data assume that selective pressures are constant over time...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01581-17
更新日期:2017-10-03 00:00:00
abstract::The saw-toothed grain beetle, Oryzaephilus surinamensis (Silvanidae), is a cosmopolitan stored-product pest. Early studies on O. surinamensis in the 1930s described the presence of peculiar bacteriomes harboring endosymbiotic bacteria in the abdomen. Since then, however, the microbiological nature of the symbiont has ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01482-17
更新日期:2017-09-26 00:00:00
abstract::The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels an...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01205-17
更新日期:2017-09-19 00:00:00
abstract::Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobact...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01238-17
更新日期:2017-09-12 00:00:00
abstract::Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we screened the Nebraska Transpo...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01114-17
更新日期:2017-09-05 00:00:00
abstract::In immunocompromised hosts, latent infection with Toxoplasma gondii can reactivate from tissue cysts, leading to encephalitis. A characteristic of T. gondii bradyzoites in tissue cysts is the presence of amylopectin granules. The regulatory mechanisms and role of amylopectin accumulation in this organism are not fully...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01289-17
更新日期:2017-08-29 00:00:00
abstract::Our knowledge of cell cycle regulatory mechanisms in apicomplexan parasites is very limited. In this study, we describe a novel Toxoplasma gondii factor that has a vital role in chromosome replication and the regulation of cytoplasmic and nuclear mitotic structures, and we named this factor ECR1 for essential for chro...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00579-17
更新日期:2017-08-22 00:00:00
abstract::Legionella pneumophila grows within cells ranging from environmental amoebae to human macrophages. In spite of this conserved strategy of pathogenesis, identification of host factors that restrict L. pneumophila intracellular replication has not been extended outside components of the mammalian innate immune response....
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02345-16
更新日期:2017-08-22 00:00:00
abstract::Yellow fever virus (YFV) is an arthropod-borne flavivirus, infecting ~200,000 people worldwide annually and causing about 30,000 deaths. The live attenuated vaccine strain, YFV-17D, has significantly contributed in controlling the global burden of yellow fever worldwide. However, the viral and host contributions to YF...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00819-17
更新日期:2017-08-15 00:00:00
abstract::Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor Pho7, a member of the Zn2Cys6 family of fungal transcription regulators, is the central player in the starvation response. The DNA binding...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01218-17
更新日期:2017-08-15 00:00:00
abstract::The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost exclusively on homologous recombination (HR), due to a lack of efficient nonhom...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00547-17
更新日期:2017-08-08 00:00:00
abstract::The Pseudomonas quinolone signal (PQS) is an important quorum-sensing molecule in Pseudomonas aeruginosa that also mediates its own packaging and transport by stimulating outer membrane vesicle (OMV) formation. Because OMVs have been implicated in many virulence-associated behaviors, it is critical that we understand ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01034-17
更新日期:2017-08-08 00:00:00
abstract::Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacter...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00887-17
更新日期:2017-08-01 00:00:00
abstract::The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as an important indicator that the golden era of antibiotics is unde...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00540-17
更新日期:2017-07-25 00:00:00
abstract::Plant roots support complex microbial communities that can influence plant growth, nutrition, and health. While extensive characterizations of the composition and spatial compartmentalization of these communities have been performed in different plant species, there is relatively little known about the impact of abiot...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00764-17
更新日期:2017-07-18 00:00:00
abstract::The growing ubiquity of electronic devices is increasingly consuming substantial energy and rare resources for materials fabrication, as well as creating expansive volumes of toxic waste. This is not sustainable. Electronic biological materials (e-biologics) that are produced with microbes, or designed with microbial ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00695-17
更新日期:2017-06-27 00:00:00
abstract::The yeast Yarrowia lipolytica is a potent accumulator of lipids, and lipogenesis in this organism can be influenced by a variety of factors, such as genetics and environmental conditions. Using a multifactorial study, we elucidated the effects of both genetic and environmental factors on regulation of lipogenesis in Y...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00857-17
更新日期:2017-06-20 00:00:00
abstract::The major oxidative stress response in Streptomyces is controlled by the sigma factor SigR and its cognate antisigma factor RsrA, and SigR activity is tightly controlled through multiple mechanisms at both the transcriptional and posttranslational levels. Here we show that sigR has a highly unusual GTC start codon and...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00815-17
更新日期:2017-06-13 00:00:00
abstract::Lateral gene transfer (LGT) profoundly shapes the evolution of bacterial lineages. LGT across disparate phylogenetic groups and genome content diversity between related organisms suggest a model of bacterial evolution that views LGT as rampant and promiscuous. It has even driven the argument that species concepts and ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00644-17
更新日期:2017-06-06 00:00:00
abstract::Murein lipoprotein (Lpp) and peptidoglycan-associated lipoprotein (Pal) are major outer membrane lipoproteins in Escherichia coli Their roles in cell-envelope integrity have been documented in E. coli laboratory strains, and while Lpp has been linked to serum resistance in vitro, the underlying mechanism has not been ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00603-17
更新日期:2017-05-23 00:00:00
abstract::Resistance-nodulation-division (RND) superfamily efflux systems have been widely studied for their role in antibiotic resistance, but their native biological functions remain poorly understood. We previously showed that loss of RND-mediated efflux in Vibrio cholerae resulted in activation of the Cpx two-component regu...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00126-17
更新日期:2017-05-16 00:00:00
abstract::The diversity of the genetic code systems used by microbes on earth is yet to be elucidated. It is known that certain methanogenic archaea employ an alternative system for cysteine (Cys) biosynthesis and encoding; tRNACys is first acylated with phosphoserine (Sep) by O-phosphoseryl-tRNA synthetase (SepRS) and then con...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00561-17
更新日期:2017-05-09 00:00:00
abstract::Photosynthetic bacteria are capable of producing their own food via photosynthesis. Unsurprisingly, they evolved the ability to move toward better light conditions (i.e., phototaxis). In a recent article in mBio, Chau et al. tuned the wavelength, flux, direction, and timing of light input and characterized the motilit...
journal_title:mBio
pub_type: 评论,杂志文章
doi:10.1128/mBio.00498-17
更新日期:2017-04-11 00:00:00
abstract::Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antagonist function, ide...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00368-17
更新日期:2017-04-04 00:00:00
abstract::SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes,...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00288-17
更新日期:2017-03-28 00:00:00
abstract::Neisseria meningitidis (the meningococcus) is primarily a commensal of the human oropharynx that sporadically causes septicemia and meningitis. Meningococci adapt to diverse local host conditions differing in nutrient supply, like the nasopharynx, blood, and cerebrospinal fluid, by changing metabolism and protein repe...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02293-16
更新日期:2017-03-21 00:00:00
abstract::Epidemiological studies on Streptococcus pneumoniae show that rates of carriage are highest in early childhood and that the major benefit of the pneumococcal conjugate vaccine (PCV) is a reduction in the incidence of nasopharyngeal colonization through decreased transmission within a population. In this study, we soug...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00188-17
更新日期:2017-03-14 00:00:00
abstract::The pathogenic species of Cryptococcus are a major cause of mortality owing to severe infections in immunocompromised as well as immunocompetent individuals. Although antifungal treatment is usually effective, many patients relapse after treatment, and in such cases, comparative analyses of the genomes of incident and...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00166-17
更新日期:2017-03-07 00:00:00
abstract::We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, that both PRC2 and euchromatic...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00133-17
更新日期:2017-02-28 00:00:00
abstract::Enterococci are ancient commensal bacteria that recently emerged as leading causes of antibiotic-resistant, hospital-acquired infection. Vancomycin-resistant enterococci (VRE) epitomize why drug-resistant enterococcal infections are a problem: VRE readily colonize the antibiotic-perturbed gastrointestinal (GI) tract w...
journal_title:mBio
pub_type: 评论,杂志文章
doi:10.1128/mBio.00066-17
更新日期:2017-02-21 00:00:00
abstract::The genetic and biochemical basis of perchlorate-dependent H2S oxidation (PSOX) was investigated in the dissimilatory perchlorate-reducing microorganism (DPRM) Azospira suillum PS (PS). Previously, it was shown that all known DPRMs innately oxidize H2S, producing elemental sulfur (So). Although the process involving P...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02023-16
更新日期:2017-02-21 00:00:00
abstract::Membrane repair emerges as an innate defense protecting target cells against bacterial pore-forming toxins. Here, we report the first paradigm of Ca2+-dependent repair following attack by a small β-pore-forming toxin, namely, plasmid-encoded phobalysin of Photobacterium damselae subsp. damselae In striking contrast, V...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02083-16
更新日期:2017-02-14 00:00:00
abstract::Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved am...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02213-16
更新日期:2017-02-07 00:00:00
abstract::Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02211-16
更新日期:2017-01-31 00:00:00
abstract::Catabolite control protein A (CcpA) is the master regulator in Gram-positive bacteria that mediates carbon catabolite repression (CCR) and carbon catabolite activation (CCA), two fundamental regulatory mechanisms that enable competitive advantages in carbon catabolism. It is generally regarded that CcpA exerts its reg...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02004-16
更新日期:2017-01-24 00:00:00
abstract::For decades, identifying the regions of a bacterial chromosome that are necessary for viability has relied on mapping integration sites in libraries of random transposon mutants to find loci that are unable to sustain insertion. To date, these studies have analyzed subsaturated libraries, necessitating the application...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02133-16
更新日期:2017-01-17 00:00:00
abstract::Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02161-16
更新日期:2017-01-03 00:00:00